Vitamin D from different sources is inversely associated with Parkinson disease.
Identifieur interne : 000008 ( Main/Exploration ); précédent : 000007; suivant : 000009Vitamin D from different sources is inversely associated with Parkinson disease.
Auteurs : Liyong Wang [États-Unis] ; Marian L. Evatt ; Lizmarie G. Maldonado ; William R. Perry ; James C. Ritchie ; Gary W. Beecham ; Eden R. Martin ; Jonathan L. Haines ; Margaret A. Pericak-Vance ; Jeffery M. Vance ; William K. ScottSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n = 478) and controls (n = 431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D < 20 ng/mL) and vitamin D insufficiency (total 25[OH]D < 30 ng/mL) are associated with PD risk (odds ratio [OR] = 2.6 [deficiency] and 2.1 [insufficiency]; P < 0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (P(trend) < 0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (P(trend) = 0.0008 and 0.12 in individuals with 25[OH]D3 < 20 ng/mL and 25[OH]D3 ≥ 20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.
DOI: 10.1002/mds.26117
PubMed: 25545356
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000308
- to stream PubMed, to step Curation: 000308
- to stream PubMed, to step Checkpoint: 000007
- to stream Ncbi, to step Merge: 004201
- to stream Ncbi, to step Curation: 004201
- to stream Ncbi, to step Checkpoint: 004201
- to stream Main, to step Merge: 000008
- to stream Main, to step Curation: 000008
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin D from different sources is inversely associated with Parkinson disease.</title><author><name sortKey="Wang, Liyong" sort="Wang, Liyong" uniqKey="Wang L" first="Liyong" last="Wang">Liyong Wang</name><affiliation wicri:level="2"><nlm:affiliation>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Evatt, Marian L" sort="Evatt, Marian L" uniqKey="Evatt M" first="Marian L" last="Evatt">Marian L. Evatt</name></author><author><name sortKey="Maldonado, Lizmarie G" sort="Maldonado, Lizmarie G" uniqKey="Maldonado L" first="Lizmarie G" last="Maldonado">Lizmarie G. Maldonado</name></author><author><name sortKey="Perry, William R" sort="Perry, William R" uniqKey="Perry W" first="William R" last="Perry">William R. Perry</name></author><author><name sortKey="Ritchie, James C" sort="Ritchie, James C" uniqKey="Ritchie J" first="James C" last="Ritchie">James C. Ritchie</name></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M" last="Vance">Jeffery M. Vance</name></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25545356</idno><idno type="pmid">25545356</idno><idno type="doi">10.1002/mds.26117</idno><idno type="wicri:Area/PubMed/Corpus">000308</idno><idno type="wicri:Area/PubMed/Curation">000308</idno><idno type="wicri:Area/PubMed/Checkpoint">000007</idno><idno type="wicri:Area/Ncbi/Merge">004201</idno><idno type="wicri:Area/Ncbi/Curation">004201</idno><idno type="wicri:Area/Ncbi/Checkpoint">004201</idno><idno type="wicri:Area/Main/Merge">000008</idno><idno type="wicri:Area/Main/Curation">000008</idno><idno type="wicri:Area/Main/Exploration">000008</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vitamin D from different sources is inversely associated with Parkinson disease.</title><author><name sortKey="Wang, Liyong" sort="Wang, Liyong" uniqKey="Wang L" first="Liyong" last="Wang">Liyong Wang</name><affiliation wicri:level="2"><nlm:affiliation>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Evatt, Marian L" sort="Evatt, Marian L" uniqKey="Evatt M" first="Marian L" last="Evatt">Marian L. Evatt</name></author><author><name sortKey="Maldonado, Lizmarie G" sort="Maldonado, Lizmarie G" uniqKey="Maldonado L" first="Lizmarie G" last="Maldonado">Lizmarie G. Maldonado</name></author><author><name sortKey="Perry, William R" sort="Perry, William R" uniqKey="Perry W" first="William R" last="Perry">William R. Perry</name></author><author><name sortKey="Ritchie, James C" sort="Ritchie, James C" uniqKey="Ritchie J" first="James C" last="Ritchie">James C. Ritchie</name></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name></author><author><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M" last="Vance">Jeffery M. Vance</name></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n = 478) and controls (n = 431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D < 20 ng/mL) and vitamin D insufficiency (total 25[OH]D < 30 ng/mL) are associated with PD risk (odds ratio [OR] = 2.6 [deficiency] and 2.1 [insufficiency]; P < 0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (P(trend) < 0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (P(trend) = 0.0008 and 0.12 in individuals with 25[OH]D3 < 20 ng/mL and 25[OH]D3 ≥ 20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><noCountry><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><name sortKey="Evatt, Marian L" sort="Evatt, Marian L" uniqKey="Evatt M" first="Marian L" last="Evatt">Marian L. Evatt</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><name sortKey="Maldonado, Lizmarie G" sort="Maldonado, Lizmarie G" uniqKey="Maldonado L" first="Lizmarie G" last="Maldonado">Lizmarie G. Maldonado</name><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R" last="Martin">Eden R. Martin</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Perry, William R" sort="Perry, William R" uniqKey="Perry W" first="William R" last="Perry">William R. Perry</name><name sortKey="Ritchie, James C" sort="Ritchie, James C" uniqKey="Ritchie J" first="James C" last="Ritchie">James C. Ritchie</name><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name><name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M" last="Vance">Jeffery M. Vance</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Wang, Liyong" sort="Wang, Liyong" uniqKey="Wang L" first="Liyong" last="Wang">Liyong Wang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000008 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000008 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25545356
|texte= Vitamin D from different sources is inversely associated with Parkinson disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25545356" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |